Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 366)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0522332	0.0998209	0.6062654
Weighted median	23	-0.0062459	0.0552352	0.9099685
Inverse variance weighted	23	-0.0249344	0.0390158	0.5227678
Simple mode	23	0.0480682	0.0908615	0.6020839
Weighted mode	23	-0.0021384	0.0651678	0.9741192

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.88735	21	0.8285614
Inverse variance weighted	14.97563	22	0.8632818

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016764	0.0056424	0.7692998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004662	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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