Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 365)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1433949	0.0998204	0.1655838
Weighted median	23	0.0707554	0.0527668	0.1799501
Inverse variance weighted	23	0.0750527	0.0390157	0.0543979
Simple mode	23	0.0722582	0.0911763	0.4365260
Weighted mode	23	0.0749269	0.0649823	0.2612705

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.30927	21	0.9308899
Inverse variance weighted	12.86254	22	0.9369241

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041969	0.0056423	0.4652263

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005019	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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