Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 364)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0729169	0.1284213	0.5761955
Weighted median	23	0.0248512	0.0621372	0.6891995
Inverse variance weighted	23	0.0125022	0.0496463	0.8011766
Simple mode	23	-0.0403691	0.1142540	0.7272059
Weighted mode	23	0.0106410	0.0716109	0.8832274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.75899	21	0.0300026
Inverse variance weighted	35.62333	22	0.0333094

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052456	0.007259	0.4778775

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010825	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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