Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 363)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0950478	0.1163991	0.4233419
Weighted median	23	0.0335737	0.0595111	0.5726457
Inverse variance weighted	23	-0.0361132	0.0460084	0.4324972
Simple mode	23	0.0020151	0.1326727	0.9880187
Weighted mode	23	0.0611462	0.0842488	0.4756237

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.55567	21	0.1250841
Inverse variance weighted	30.59357	22	0.1047368

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080546	0.0065795	0.2344315

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000953	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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