Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 362)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1169885	0.0998193	0.2543212
Weighted median	23	-0.1286926	0.0567356	0.0233117
Inverse variance weighted	23	-0.0758556	0.0390154	0.0518658
Simple mode	23	-0.0914000	0.0985217	0.3636231
Weighted mode	23	-0.1191239	0.0680988	0.0941820

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.15198	21	0.5753916
Inverse variance weighted	19.35240	22	0.6234786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002526	0.0056423	0.658963

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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