Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 361)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0843599	0.1113994	0.4572989
Weighted median	23	0.0164593	0.0550639	0.7650067
Inverse variance weighted	23	0.0134339	0.0430221	0.7548467
Simple mode	23	0.0317311	0.1026094	0.7600472
Weighted mode	23	0.0385745	0.0607075	0.5317121

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.15435	21	0.2006249
Inverse variance weighted	26.75024	22	0.2208665

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043556	0.0062968	0.4966983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008142	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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