Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 360)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0291372	0.0998206	0.7732303
Weighted median	23	0.0552102	0.0566249	0.3295524
Inverse variance weighted	23	0.0303200	0.0390157	0.4370857
Simple mode	23	0.0101215	0.1022091	0.9220132
Weighted mode	23	0.0519783	0.0673266	0.4483097

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.75590	21	0.834998
Inverse variance weighted	15.17466	22	0.854634

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036513	0.0056423	0.5245663

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004782	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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