Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 359)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2130684	0.1293896	0.1144999
Weighted median	23	0.1216576	0.0559488	0.0296716
Inverse variance weighted	23	0.0574144	0.0513803	0.2638064
Simple mode	23	0.1181774	0.0921795	0.2131763
Weighted mode	23	0.1257353	0.0579299	0.0410401

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.28510	21	0.0262662
Inverse variance weighted	38.15517	22	0.0176007

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0095587	0.0073137	0.2053599

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012217	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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