Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 358)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0857631	0.1156368	0.4665080
Weighted median	23	0.0042746	0.0592469	0.9424841
Inverse variance weighted	23	-0.0045070	0.0449085	0.9200594
Simple mode	23	-0.0465746	0.1081644	0.6709551
Weighted mode	23	-0.0185482	0.0871522	0.8334227

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.18328	21	0.1350295
Inverse variance weighted	29.14859	22	0.1406672

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055435	0.0065364	0.4059453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008836	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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