Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 357)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0723875	0.1236505	0.5645036
Weighted median	23	0.0273884	0.0634213	0.6658520
Inverse variance weighted	23	-0.0177149	0.0479180	0.7116125
Simple mode	23	-0.1808353	0.1487634	0.2370251
Weighted mode	23	-0.1668613	0.1185056	0.1730923

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.22468	21	0.0555529
Inverse variance weighted	33.18640	22	0.0592995

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055333	0.0069894	0.4374091

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010118	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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