Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 356)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0281659	0.0998209	0.7805796
Weighted median	23	-0.0302503	0.0550596	0.5827241
Inverse variance weighted	23	-0.0444392	0.0390159	0.2547020
Simple mode	23	-0.0160535	0.0878418	0.8566644
Weighted mode	23	-0.0484831	0.0652956	0.4656296

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.09896	21	0.8179538
Inverse variance weighted	15.13033	22	0.8565845

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009993	0.0056423	0.8611161

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004978	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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