Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 355)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2373621	0.1053635	0.0350931
Weighted median	23	-0.1186864	0.0570833	0.0376009
Inverse variance weighted	23	-0.0492140	0.0436926	0.2600092
Simple mode	23	-0.0732028	0.0962730	0.4551076
Weighted mode	23	-0.0955903	0.0622019	0.1386074

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.39747	21	0.3231576
Inverse variance weighted	27.59089	22	0.1896385

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0115541	0.0059556	0.0659234

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008842	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8