Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 354)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0569200	0.1180180	0.6345821
Weighted median	23	0.0015615	0.0628982	0.9801940
Inverse variance weighted	23	0.0419324	0.0459479	0.3614483
Simple mode	23	-0.0512940	0.1128045	0.6537689
Weighted mode	23	0.0024716	0.0854295	0.9771798

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.35580	21	0.1057182
Inverse variance weighted	30.51338	22	0.1065111

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060705	0.0066709	0.3731523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009596	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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