Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 353)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0358010	0.1115637	0.7514565
Weighted median	23	0.0396598	0.0540151	0.4628052
Inverse variance weighted	23	0.0276047	0.0426094	0.5170797
Simple mode	23	0.0428293	0.0969675	0.6630269
Weighted mode	23	0.0106039	0.0642227	0.8703641

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.23180	21	0.1977480
Inverse variance weighted	26.23976	22	0.2415305

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005033	0.0063061	0.9371387

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008103	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8