Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 352)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0988715	0.1020739	0.3437559
Weighted median	23	-0.0731836	0.0591199	0.2157591
Inverse variance weighted	23	0.0069594	0.0401392	0.8623508
Simple mode	23	-0.0736097	0.1111995	0.5148712
Weighted mode	23	-0.0829410	0.0726787	0.2660565

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.95891	21	0.4018813
Inverse variance weighted	23.28564	22	0.3857534

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064991	0.0057697	0.2726996

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007066	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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