Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 351)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2604412	0.1159937	0.0356428
Weighted median	23	0.0420915	0.0598139	0.4816152
Inverse variance weighted	23	0.0396856	0.0485958	0.4141302
Simple mode	23	0.1134784	0.0994378	0.2660574
Weighted mode	23	0.0899499	0.0664992	0.1899090

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.35824	21	0.1302807
Inverse variance weighted	34.13143	22	0.0476331

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0135567	0.0065566	0.0512149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010656	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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