Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 350)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0537573	0.0998208	0.5958685
Weighted median	23	0.0061743	0.0535426	0.9081951
Inverse variance weighted	23	0.0110434	0.0390156	0.7771377
Simple mode	23	-0.0117739	0.0889065	0.8958481
Weighted mode	23	0.0105417	0.0586243	0.8589413

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.97805	21	0.6503929
Inverse variance weighted	18.19417	22	0.6944159

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002623	0.0056423	0.6467967

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005538	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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