Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 35)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1221006	0.1127954	0.2913059
Weighted median	23	0.0290526	0.0598285	0.6272524
Inverse variance weighted	23	-0.0243895	0.0450688	0.5883969
Simple mode	23	0.0392370	0.1027345	0.7061802
Weighted mode	23	0.0425433	0.0719936	0.5605889

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.81455	21	0.1770761
Inverse variance weighted	29.35660	22	0.1349586

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089959	0.0063757	0.1728985

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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