Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 349)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0348486	0.1067544	0.7473250
Weighted median	23	-0.0161560	0.0620227	0.7944900
Inverse variance weighted	23	-0.0456967	0.0407781	0.2624502
Simple mode	23	-0.2069336	0.1087204	0.0701595
Weighted mode	23	0.0079290	0.0783670	0.9203254

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.01937	21	0.2921208
Inverse variance weighted	24.03331	22	0.3454856

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006662	0.0060343	0.9131403

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007698	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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