Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 348)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1688512	0.0998188	0.1055148
Weighted median	23	0.0387303	0.0584378	0.5074832
Inverse variance weighted	23	0.0601991	0.0390150	0.1228375
Simple mode	23	0.0142350	0.1139586	0.9017263
Weighted mode	23	-0.0001045	0.1210991	0.9993193

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.33700	21	0.8056703
Inverse variance weighted	16.73546	22	0.7777883

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0066724	0.0056423	0.2501986

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005792	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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