Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 347)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0277702	0.0998199	0.7835775
Weighted median	23	0.0476357	0.0561129	0.3959226
Inverse variance weighted	23	0.0015083	0.0390156	0.9691615
Simple mode	23	0.0673628	0.0956511	0.4886623
Weighted mode	23	0.0761618	0.0669108	0.2672570

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.47505	21	0.7423944
Inverse variance weighted	16.55675	22	0.7873275

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016127	0.0056423	0.7778089

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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