Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 346)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0039136	0.1016223	0.9696441
Weighted median	23	-0.0164314	0.0556809	0.7679177
Inverse variance weighted	23	-0.0320195	0.0390155	0.4118250
Simple mode	23	-0.0632227	0.0911975	0.4954071
Weighted mode	23	-0.0097300	0.0599722	0.8725965

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.76509	21	0.4131535
Inverse variance weighted	21.85866	22	0.4683514

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001726	0.0057442	0.7667695

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006828	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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