Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 345)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0265916	0.0998198	0.7925327
Weighted median	23	0.0193484	0.0563220	0.7311977
Inverse variance weighted	23	0.0052263	0.0390155	0.8934390
Simple mode	23	-0.0476300	0.1091105	0.6667067
Weighted mode	23	0.0866027	0.0786347	0.2826570

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.19364	21	0.5090274
Inverse variance weighted	20.31356	22	0.5634329

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019539	0.0056423	0.7325621

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006161	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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