Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 344)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1254872	0.0998208	0.2225110
Weighted median	23	-0.0151213	0.0578712	0.7938673
Inverse variance weighted	23	-0.0019589	0.0390156	0.9599566
Simple mode	23	-0.0092159	0.0944390	0.9231445
Weighted mode	23	-0.0203106	0.0693871	0.7724831

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.29594	21	0.7527996
Inverse variance weighted	18.10348	22	0.6998354

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075859	0.0056424	0.1931469

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005487	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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