Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 343)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1550701	0.0998184	0.1352403
Weighted median	23	0.0148324	0.0622576	0.8116931
Inverse variance weighted	23	-0.0237298	0.0392731	0.5456948
Simple mode	23	0.0620166	0.1269066	0.6299048
Weighted mode	23	-0.1592678	0.1018242	0.1320553

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.2486	21	0.5055671
Inverse variance weighted	22.2921	22	0.4425738

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080657	0.0056423	0.1675666

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006867	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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