Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 342)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1019700	0.1136382	0.3797198
Weighted median	23	0.0369916	0.0552009	0.5027770
Inverse variance weighted	23	0.0138092	0.0441230	0.7543027
Simple mode	23	0.0109502	0.1043783	0.9173991
Weighted mode	23	0.0394809	0.0632371	0.5388312

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.21617	21	0.1638119
Inverse variance weighted	28.13685	22	0.1711900

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054139	0.0064233	0.4088099

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008564	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8