Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 340)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0077536	0.0998203	0.9388213
Weighted median	23	-0.0462885	0.0588977	0.4319186
Inverse variance weighted	23	0.0019382	0.0390156	0.9603785
Simple mode	23	-0.0834350	0.0952262	0.3904008
Weighted mode	23	-0.0672963	0.0724355	0.3629453

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.69156	21	0.7296252
Inverse variance weighted	16.69557	22	0.7799324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003571	0.0056423	0.9501314

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000506	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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