Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 34)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0538926	0.0998206	0.5949495
Weighted median	23	-0.0393115	0.0555761	0.4793510
Inverse variance weighted	23	-0.0579565	0.0390155	0.1374185
Simple mode	23	-0.0432516	0.0877522	0.6269786
Weighted mode	23	-0.0373461	0.0690764	0.5941819

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.34698	21	0.6898704
Inverse variance weighted	17.34894	22	0.7438169

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002496	0.0056423	0.965138

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005926	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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