Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 339)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0907345	0.0998197	0.3736730
Weighted median	23	-0.0150605	0.0607800	0.8042994
Inverse variance weighted	23	-0.0620459	0.0390154	0.1117688
Simple mode	23	0.0101585	0.1100762	0.9273059
Weighted mode	23	0.0059604	0.0940058	0.9500166

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.61093	21	0.8857243
Inverse variance weighted	16.37597	22	0.7967981

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093823	0.0056423	0.1111988

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005729	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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