Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 338)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0704557	0.0998206	0.4880550
Weighted median	23	-0.0456852	0.0563552	0.4175582
Inverse variance weighted	23	-0.0237270	0.0390156	0.5430931
Simple mode	23	0.0595132	0.0986734	0.5525875
Weighted mode	23	-0.0529506	0.0689101	0.4504192

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.93197	21	0.6533054
Inverse variance weighted	18.19062	22	0.6946283

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028696	0.0056423	0.6163458

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005624	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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