Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 337)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0535735	0.0998202	0.5971154
Weighted median	23	0.0781013	0.0536991	0.1458287
Inverse variance weighted	23	0.0408923	0.0390157	0.2945925
Simple mode	23	0.0773545	0.0810493	0.3502447
Weighted mode	23	0.0714657	0.0611987	0.2554023

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.62756	21	0.6724358
Inverse variance weighted	17.64661	22	0.7267231

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007788	0.0056423	0.8915395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000568	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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