Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 336)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0472481 0.1062105 0.6609768
Weighted median 23 -0.0356489 0.0560220 0.5245567
Inverse variance weighted 23 0.0081071 0.0407134 0.8421643
Simple mode 23 -0.0263973 0.0838733 0.7559332
Weighted mode 23 -0.0333827 0.0570929 0.5646930

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.77442 21 0.3041163
Inverse variance weighted 23.95590 22 0.3495454

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0024036 0.0060035 0.6929258

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007272 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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