Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 335)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0082968	0.0998209	0.9345456
Weighted median	23	0.0345573	0.0544365	0.5255465
Inverse variance weighted	23	0.0306543	0.0390158	0.4320496
Simple mode	23	0.0579623	0.0927518	0.5384530
Weighted mode	23	0.0474827	0.0617853	0.4503548

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.41284	21	0.8016815
Inverse variance weighted	15.47205	22	0.8411966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001373	0.0056423	0.8101091

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004876	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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