Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 334)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0749977	0.0998187	0.4607864
Weighted median	23	0.0474224	0.0561962	0.3987418
Inverse variance weighted	23	0.0265480	0.0390154	0.4962203
Simple mode	23	0.0502876	0.1007315	0.6225772
Weighted mode	23	0.0723517	0.0733550	0.3346987

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.30879	21	0.8559736
Inverse variance weighted	14.58686	22	0.8793497

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029753	0.0056423	0.603494

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004561	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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