Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 333)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1379224	0.1103610	0.2251443
Weighted median	23	0.0208967	0.0585204	0.7210286
Inverse variance weighted	23	0.0125373	0.0436457	0.7739197
Simple mode	23	-0.0449484	0.1066076	0.6773902
Weighted mode	23	-0.0294004	0.0833347	0.7275969

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.66941	21	0.2193359
Inverse variance weighted	27.53173	22	0.1917232

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0076999	0.0062381	0.2307166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008374	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8