Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 332)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0344881	0.0998208	0.7331553
Weighted median	23	0.0433232	0.0556216	0.4360437
Inverse variance weighted	23	0.0141915	0.0390156	0.7160537
Simple mode	23	0.1500784	0.0978116	0.1391972
Weighted mode	23	-0.0524113	0.0730458	0.4806078

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.48921	21	0.9254602
Inverse variance weighted	12.76991	22	0.9393801

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029894	0.0056424	0.601797

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000391	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8