Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 331)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0707596	0.0998212	0.4862049
Weighted median	23	0.0471956	0.0577278	0.4136115
Inverse variance weighted	23	0.0616171	0.0390526	0.1146120
Simple mode	23	0.0629014	0.0914340	0.4986787
Weighted mode	23	0.0417258	0.0645360	0.5246112

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.96600	21	0.5234160
Inverse variance weighted	22.04175	22	0.4573993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081292	0.0056424	0.1644012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007435	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8