Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 330)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0144738	0.1088094	0.8954442
Weighted median	23	-0.0162393	0.0591568	0.7836909
Inverse variance weighted	23	0.0212548	0.0416768	0.6100572
Simple mode	23	-0.0471269	0.1081892	0.6673727
Weighted mode	23	-0.0205374	0.0788429	0.7969123

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.95273	21	0.2492173
Inverse variance weighted	25.10394	22	0.2921298

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021941	0.0061504	0.7248477

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007697	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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