Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 329)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0880194	0.0998204	0.3878790
Weighted median	23	0.0367027	0.0564008	0.5152090
Inverse variance weighted	23	0.0309980	0.0390157	0.4269030
Simple mode	23	0.1239868	0.0934942	0.1983964
Weighted mode	23	0.0953243	0.0744609	0.2138120

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	8.449466	21	0.9929246
Inverse variance weighted	8.834620	22	0.9941507

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035017	0.0056424	0.5415351

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0002868	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8