Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 328)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0889084	0.0998204	0.3831897
Weighted median	23	0.0435956	0.0589238	0.4593824
Inverse variance weighted	23	0.0046020	0.0390155	0.9061054
Simple mode	23	-0.1130162	0.1113975	0.3213582
Weighted mode	23	0.0751873	0.0792780	0.3532278

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.24248	21	0.7558759
Inverse variance weighted	17.08442	22	0.7586851

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051773	0.0056423	0.3692607

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005181	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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