Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 327)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0041823	0.1064795	0.9690394
Weighted median	23	0.0061775	0.0545869	0.9098966
Inverse variance weighted	23	0.0037050	0.0406676	0.9274093
Simple mode	23	0.0005997	0.0960815	0.9950763
Weighted mode	23	0.0005997	0.0689065	0.9931346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.89505	21	0.2981715
Inverse variance weighted	23.90242	22	0.3523652

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004844	0.0060187	0.936621

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007246	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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