Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 326)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1805399	0.0998205	0.0848483
Weighted median	23	-0.0458087	0.0558190	0.4118371
Inverse variance weighted	23	-0.0334438	0.0390155	0.3913383
Simple mode	23	0.0757696	0.0966172	0.4412710
Weighted mode	23	-0.0634400	0.0631878	0.3262989

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.37240	21	0.5612640
Inverse variance weighted	21.93548	22	0.4637457

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090332	0.0056423	0.1243229

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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