Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 325)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0645837	0.0998205	0.5246426
Weighted median	23	-0.0609702	0.0549499	0.2671885
Inverse variance weighted	23	-0.0731039	0.0390155	0.0609698
Simple mode	23	-0.1103838	0.0987487	0.2756998
Weighted mode	23	-0.0611486	0.0727166	0.4094420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.50618	21	0.6167856
Inverse variance weighted	18.51478	22	0.6750685

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005232	0.0056423	0.9269952

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006674	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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