Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 324)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1027803	0.0998202	0.3148863
Weighted median	23	-0.0570482	0.0534502	0.2858296
Inverse variance weighted	23	-0.0591370	0.0390158	0.1295900
Simple mode	23	0.0009887	0.0784698	0.9900608
Weighted mode	23	-0.0481718	0.0551511	0.3918522

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.65662	21	0.6071569
Inverse variance weighted	18.88225	22	0.6525876

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026801	0.0056423	0.6396857

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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