Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 323)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0970158	0.1085267	0.3814880
Weighted median	23	-0.0050996	0.0592799	0.9314457
Inverse variance weighted	23	0.0142560	0.0421150	0.7349844
Simple mode	23	0.0577879	0.1060019	0.5911288
Weighted mode	23	-0.0341531	0.0753606	0.6548458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.82307	21	0.2549083
Inverse variance weighted	25.63441	22	0.2677093

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050823	0.0061345	0.4167163

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007808	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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