Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 322)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2471914	0.1122076	0.0389005
Weighted median	23	-0.1239647	0.0614009	0.0434936
Inverse variance weighted	23	-0.0776216	0.0455163	0.0881277
Simple mode	23	-0.1304127	0.1082735	0.2412044
Weighted mode	23	-0.1304127	0.0723209	0.0850634

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.53653	21	0.1867254
Inverse variance weighted	29.94279	22	0.1198616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104133	0.0063425	0.1155188

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010272	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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