Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 321)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1274630	0.1062760	0.2437468
Weighted median	23	0.1468808	0.0567595	0.0096597
Inverse variance weighted	23	0.1093997	0.0406173	0.0070723
Simple mode	23	0.1267068	0.1131835	0.2750088
Weighted mode	23	0.1927786	0.0815352	0.0273048

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.80557	21	0.3025744
Inverse variance weighted	23.84422	22	0.3554478

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011093	0.0060073	0.8552707

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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