Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 320)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1087932	0.0998207	0.2881122
Weighted median	23	0.0210072	0.0564605	0.7098411
Inverse variance weighted	23	0.0110876	0.0390157	0.7762710
Simple mode	23	0.0715364	0.0961985	0.4649669
Weighted mode	23	0.0315455	0.0724394	0.6674607

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.89746	21	0.5917178
Inverse variance weighted	20.02829	22	0.5812700

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0060001	0.0056424	0.2996747

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006094	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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