Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 319)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0368840	0.0998203	0.7154520
Weighted median	23	0.0676420	0.0580761	0.2441352
Inverse variance weighted	23	0.0056823	0.0390155	0.8842030
Simple mode	23	-0.0335233	0.0993679	0.7390388
Weighted mode	23	0.0648297	0.0752321	0.3981321

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.92794	21	0.5258295
Inverse variance weighted	20.04327	22	0.5803333

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019161	0.0056423	0.7375364

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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