Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 318)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0823419	0.1235614	0.5124081
Weighted median	23	-0.0005542	0.0615771	0.9928195
Inverse variance weighted	23	-0.0116691	0.0476166	0.8064068
Simple mode	23	-0.0014156	0.1116095	0.9899945
Weighted mode	23	-0.0306707	0.0764959	0.6923271

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.17792	21	0.0561655
Inverse variance weighted	32.76959	22	0.0651894

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00434	0.0069843	0.5410262

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009957	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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